Book Review: Industrialization of Drug Discovery from Target Selection through Lead Optimization
نویسندگان
چکیده
منابع مشابه
Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery
The central nervous system (CNS) is the major area that is affected by aging. Alzheimer's disease (AD), Parkinson's disease (PD), brain cancer, and stroke are the CNS diseases that will cost trillions of dollars for their treatment. Achievement of appropriate blood-brain barrier (BBB) penetration is often considered a significant hurdle in the CNS drug discovery process. On the other hand, BBB ...
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Introduction We investigate discovery in pharmacology by following and analyzing the progress of research on drugs for Parkinson’s disease at our local pharmacology department. In pharmacology research detailed knowledge of biological processes is used to provide a rationale for a desired biological activity of a drug. This desired activity should cause a decrease in disease symptoms and is cal...
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Critical to the discovery and development of drugs and vaccines is the rational selection of biochemical, immunologic or molecular targets. To understand the rationale for target selection, we review strengths and weaknesses of the four main approaches: whole animal disease models; molecular targeting; epidemiology/observation studies, and genomics. After classifying diseases into those with a ...
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The book ‘Developing expertise through experience’consists of twenty chapters written by language educators. Alan Maley has edited the book. The writers of the chapters have written their stories and experiences about learning English and being an Educator with regard to the notion of ‘sense of plausibility’ defined by Prabhu. Prabhu explains that plausibility in pedagogy is teachers’ intuition...
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The advances of genomics, sequencing, and high throughput technologies have led to the creation of large volumes of diverse datasets for drug discovery. Analyzing these datasets to better understand disease and discover new drugs is becoming more common. Recent open data initiatives in basic and clinical research have dramatically increased the types of data available to the public. The past fe...
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ژورنال
عنوان ژورنال: Journal of Biomolecular Screening
سال: 2005
ISSN: 1087-0571,1552-454X
DOI: 10.1177/1087057106286191